THE SMART TRICK OF PKRRATING THAT NOBODY IS DISCUSSING

) mechanism16,thirty–34 [for your Opposite perspective see35]. The BTB dimer orients the active internet sites clear of the dimer interface inside a configuration that cannot mediate this reaction. Here, we report constructions of wild-type, unphosphorylated PKR kinase. The kinase domains interact through the BTB interface and undertake an Lively